The facility is designed primarily to produce two types of biological products from established cell lines: (1) clinical grade, intended for intravenous administration in humans and (2) non-clinical grade for use in research models.
Manufacture and purification of products are performed in dedicated clinical and non-clinical areas of the facility in compliance with regulatory standards. The facility maintains stringent quality control standards for each step of the production process. Production of biological agents includes: monoclonal antibodies, fusion proteins, plasmids, formulation of peptide vaccines, and various other products derived from both eukaryotic and prokaryotic culture systems.
Other Services include:
The resource provides support for reproducible production of human hematopoietic or immuno-competent cells under stringent quality control and safety conditions required for therapeutic studies. Cell production services include enrichment or depletion of specific cell subsets, provision of normal donor feeder cells, maintenance of transformed feeder cell lines, cloning, ex-vivo antigen priming, cytokine and antibody-based activation, genetic modification, expansion, cryopreservation and/or preparation for infusion of many different types of extensively manipulated cell populations.
To initiate service or obtain additional information, contact the facility director (x5838). Projects are scheduled following the submission of appropriate service request forms.
